Links overviews , and here Sildenafil – current trials Uses of sildenafil in cardiovascular disease with pulmonary hypertension Thalidomide Good overview https://pubs.rsc.org/en/content/chapterhtml/2022/bk9781788019033-00001?isbn=978-1-78801-903-3&sercode=bk#cit7 and re myeloma leprosy mirena coil NHS policy and here overall drug development stats

Redirect study https://www.gla.ac.uk/researchinstitutes/healthwellbeing/news/headline_798822_en.html, https://redirectstudy.co.uk/ NIHR list here of trials  https://www.nihr.ac.uk/news/196-million-awarded-to-new-research-studies-to-help-diagnose-and-treat-long-covid/282

references: BJSM systematic review and meta analysis Definitions https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4269139/ International practice guidelines https://link.springer.com/content/pdf/10.1007/s12603-018-1139-9.pdf Screening – tests perform poorly BMJ analysis Arguments for it as a disease systematic review on resistance training for adults and for prevention/treatment and https://pubmed.ncbi.nlm.nih.gov/28549707/ and https://eurapa.biomedcentral.com/articles/10.1186/s11556-020-00243-9 and https://bjsm.bmj.com/content/54/15/885.abstract RCT on nutritional/exercise/cognitive intervention and another intervention trial Cochrane review on strength training […]

Had intended to be in London but lots of cancelled trains and I had to be back in Glasgow at the weekend. So attended remotely, it’s never quite the same. As ever I try never to repeat points someone else has made. It’s enough I think to say you agree and move on. Otherwise it […]

Links to things I’ve written before: Waterlogged? BMJ the mad colour chart (zillions of versions online, how much money have the NHS spent creating these? ffs) BMJ on this and some links to the primary science: First report I can find of using colour charts of some type to assess urine colour studies in 1990s […]

Lancet report https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02724-0/fulltext persistent urban myth that green sputum means you have a chest infection that needs antibiotics not the case. Special rules if you have serious lung condition eg cystic fibrosis or COPD, but for people who are otherwise well, green sputum does not = a need for antibiotics.  https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-021-01767-6 and https://erj.ersjournals.com/content/39/6/1354) the colour can’t distinguish between viral and bacterial […]

Study in the news (Canada) https://www.researchgate.net/profile/Angela-Jerath/publication/356887012_Association_of_Surgeon-Patient_Sex_Concordance_With_Postoperative_Outcomes/links/61b2bb4c358cc06c3f9a801b/Association-of-Surgeon-Patient-Sex-Concordance-With-Postoperative-Outcomes.pdf Other studies of note: USA study of surgery – didn’t find a link between sex of patients/surgeons and outcomes (but found the older surgeons have lower mortality rates) also found here Canadian study comparing male and female surgeons outcomes (better as elective, no difference in emergency) US study of […]

Dry January https://www.tandfonline.com/doi/full/10.1080/08870446.2020.1743840 https://www.researchgate.net/publication/339212416_Temporary_abstinence_during_Dry_January_predictors_of_success_impact_on_well-being_and_self-efficacy https://pubmed.ncbi.nlm.nih.gov/29730627/ https://bmjopen.bmj.com/content/8/5/e020673 exercise and sleep https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716674/ https://bjsm.bmj.com/content/51/5/479 https://pubmed.ncbi.nlm.nih.gov/34163383/ https://pubmed.ncbi.nlm.nih.gov/25903450/ https://www.sciencedirect.com/science/article/pii/S1836955312701066 https://ijbnpa.biomedcentral.com/articles/10.1186/s12966-020-0913-3 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385214/ making new habits https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505409/

UK Gov review (spot the non sig outcomes, the stat but not clinically sig outcomes….the lack cost effectiveness detail) https://www.gov.uk/government/publications/diabetes-prevention-programmes-evidence-review rollout analysis https://bmjopen.bmj.com/content/8/2/e019467 National guidance – NHS Healthcheck https://www.healthcheck.nhs.uk/commissioners-and-providers/national-guidance/ NICE diagnosis categories https://pathways.nice.org.uk/pathways/preventing-type-2-diabetes#path=view%3A/pathways/preventing-type-2-diabetes/managing-risk-of-type-2-diabetes.xml&content=view-node%3Anodes-high-risk good BMJ analysis on key overdiagnosis issues Click to access 760940 and another from BJGP Click to access 172.full.pdf Prevent diabetes cluster […]

Fluoride in water supplies – and old one and a good one https://www.bmj.com/content/335/7622/699.long and Scotland https://dwqr.scot/public-water-supply/drinking-water-quality-faqs/fluoride/ Cochrane review https://www.nature.com/articles/sj.bdj.2016.257 impact in Scotland Click to access NDEP_for_England_OH_Survey_5yr_2019_v1.0.pdf impact on hospital admissions https://www.nature.com/articles/s41415-021-2945-8 Consultation on folic acid https://www.gov.uk/government/consultations/adding-folic-acid-to-flour/proposal-to-add-folic-acid-to-flour-consultation-document#sacn-reports and impact assessment Click to access folic-acid-impact-assessment.pdf and https://www.gov.uk/government/consultations/adding-folic-acid-to-flour/proposal-to-add-folic-acid-to-flour-consultation-document#current-advice systematic review https://www.cambridge.org/core/journals/public-health-nutrition/article/impact-of-folic-acid-fortification-of-flour-on-neural-tube-defects-a-systematic-review/EE00B553A9BD987BADF495B21E3CCF6C controlled trial https://pubmed.ncbi.nlm.nih.gov/27005659/ impact assessment of fortification […]