Lancet study for UKCTOCS -2021 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00731-5/fulltext and 2015 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)01224-6/fulltext Puerto Rico practice https://www.hindawi.com/journals/bmri/2014/920915/ US Preventive services taskforce https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/ovarian-cancer-screening NHS advice on ovarian cancer symptoms https://www.nhs.uk/conditions/ovarian-cancer/

Yellow Card link https://coronavirus-yellowcard.mhra.gov.uk/about Government website on adverse reactions Click to access COVID-19_AstraZeneca_Vaccine_Analysis_Print.pdf York review – history of patient reporting https://aura.abdn.ac.uk/bitstream/handle/2164/2957/mon1520_YCS.pdf;jsessionid=70780E9E705E664188E0B406FFFD2605?sequence=1 https://www.gov.uk/government/publications/coronavirus-covid-19-vaccine-adverse-reactions/coronavirus-vaccine-summary-of-yellow-card-reporting Denmark pause https://www.theguardian.com/society/2021/mar/11/denmark-pauses-astrazeneca-vaccines-to-investigate-blood-clot-reports

Quarantine – historical https://journals.sagepub.com/doi/pdf/10.1177/003591574503800701 WHO and international vaccine certification https://link.springer.com/chapter/10.1007/978-3-642-73772-5_120 https://journals.sagepub.com/doi/pdf/10.1177/003591574503800701 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454779/ Click to access Green-Book-Chapter-14v2_0.pdf WHO and current guidance https://www.who.int/news-room/articles-detail/interim-position-paper-considerations-regarding-proof-of-covid-19-vaccination-for-international-travellers UK currently reviewing ‘complex issues’ https://www.bbc.co.uk/news/55970801 previous problems with IHR https://journals.sagepub.com/doi/full/10.1177/0098858816658273 loopholes with yellow fever vaccination https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31670-8/fulltext issues with apps and data security https://www.qmul.ac.uk/media/news/2021/se/new-tool-reveals-security-and-privacy-issues-with-contact-tracing-apps.html fantastic tracker from Ada Lovelace Institute https://www.adalovelaceinstitute.org/project/international-monitor-vaccine-passports-covid-status-apps/ Rabies vaccination and […]

Government press release https://www.gov.uk/government/news/worlds-first-coronavirus-human-challenge-study-receives-ethics-approval-in-the-uk Ethical issues https://www.thelancet.com/journals/laninf/article/PIIS1473-30992030438-2/fulltext Pfizer study – the numbers! https://www.nejm.org/doi/full/10.1056/NEJMoa2034577 Nuremberg trials and code https://www.nejm.org/doi/full/10.1056/nejm199711133372006 ethical frameworks https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926904/ https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30518-X/fulltext other types human challenge trials hookworm, – https://academic.oup.com/ofid/article/5/5/ofy083/4976553 malaria https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195259/ but also RSV – many trials of deliberately infecting humans https://clinicaltrials.gov/ct2/show/NCT02755948 Click to access 77021661.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904492/ Helicobacter story https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661189/ Click to access en_v31n3a02.pdf […]

Government consultation on ‘minipill’ – POP https://www.gov.uk/government/news/views-sought-on-making-the-oral-contraceptive-pill-desogestrel-available-from-pharmacies recommendations of extended use of implant and (some!) coils https://www.fsrh.org/documents/fsrh-ceu-recommendation-on-extended-use-of-the-etonogestrel/ service standards for family planning+sexual health during covid-19https://www.fsrh.org/documents/fsrh-guidance-essential-srh-services–third-covid-19-lockdown/ and https://www.fsrh.org/documents/fsrh-update-provision-of-contraception-during-covid19/

conclusion: this needs tested, may do more harm than good,  and cannot be assumed to ‘work’ Government announcement https://www.gov.uk/government/news/asymptomatic-testing-to-be-rolled-out-across-the-country-starting-this-week including “With the expansion of asymptomatic testing for those unable to work from home, added to our comprehensive COVID-Secure guidance, we can keep our economy on the move while giving individuals in key sectors complete confidence […]

initial publications https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgaa733/5934827 UK biobank Our findings do not support a potential link between vitamin D concentrations and risk of COVID-19 infection, nor that vitamin D concentration may explain ethnic differences in COVID-19 infection. https://pubmed.ncbi.nlm.nih.gov/32413819/ Lancet https://www.thelancet.com/journals/landia/article/PIIS2213-8587(20)30268-0/fulltext systematic review on vitamin D supplementation and preventing acute resp infections BMJ 2017 https://www.bmj.com/content/356/bmj.i6583 Meta-analysis of IPD from […]

https://www.cochrane.org/CD003048/INFECTN_do-probiotics-help-treat-acute-infectious-diarrhoea https://gutscharity.org.uk/advice-and-information/health-and-lifestyle/gut-microbiome-poo-testing/#section-5 https://www.bsg.org.uk/strategic-areas/research/gut-microbiota-for-health-expert-panel/ https://pubmed.ncbi.nlm.nih.gov/23439798/ https://www.nature.com/articles/s41591-020-0934-0 https://clevrblends.com/pages/faq https://academic.oup.com/cdn/article/4/Supplement_2/1547/5844467 https://academic.oup.com/cdn/article/4/Supplement_2/1518/5845874 https://www.cell.com/cell/fulltext/S0092-8674(15)01481-6#fig5 https://www.cell.com/cell/fulltext/S0092-8674(15)01481-6#secsectitle0035 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991026/

BESSI collaboration :https://www.bessi-collab.net/about-us SAGE on non drug interventions https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/925854/S0769_Summary_of_effectiveness_and_harms_of_NPIs.pdf rates of covid-19 testing https://coronavirus.data.gov.uk/?_ga=2.54504936.1326017125.1602531867-289927355.1585336355

mesh and device regulation Useful links BMJ series on mesh – this on conflicts of interest https://www.bmj.com/content/363/bmj.k4164#ref-2 and https://www.bmj.com/content/363/bmj.k4137?ijkey=32cd6095d62352451d2fca5bd0244c337314ea38&keytype2=tf_ipsecsha Europe’s device regulation https://www.bmj.com/content/363/bmj.k4205 complication rates https://www.nature.com/articles/s41598-017-11821-w systematic review https://pubmed.ncbi.nlm.nih.gov/21424785/ device testing https://ora.ox.ac.uk/objects/uuid:11925495-37a8-46c0-a39c-851ffafb88a6/download_file?file_format=pdf&safe_filename=Mahtani%2Bet%2Bal%252C%2BTransvaginal%2Bmesh%2Bfailure%2B-%2Blessons%2Bfor%2Bregulation%2Bof%2Bimplantable%2Bdevices.pdf&type_of_work=Journal+article FDA report https://www.fda.gov/media/81123/download