NICE https://www.nice.org.uk/guidance/indevelopment/gid-ta10765 NEJM Step1 https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 Step 1 extension https://pubmed.ncbi.nlm.nih.gov/35441470/ Step 5 trial (2 years) https://www.nature.com/articles/s41591-022-02026-4#:~:text=Safety%20and%20tolerability,placebo%20group%20(Table%203). Weight loss outcomes Real world outcomes in type 2 diabetes https://drc.bmj.com/content/10/1/e002517 on side effects

https://www.sehd.scot.nhs.uk/publications/NHS_Pharmacy_First_Scotland_Approved_List_of_Products_v13_(1_Dec_2021).pdf https://www.nhsinform.scot/care-support-and-rights/nhs-services/pharmacy/nhs-pharmacy-first-scotland https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692826/ https://pubmed.ncbi.nlm.nih.gov/29362007/ https://bmjopenquality.bmj.com/content/9/1/e000833 https://www.communitypharmacy.scot.nhs.uk/media/1104/pharmacy-first-guidance-document-lk-v3comments-1.pdf https://www.gov.scot/publications/nhs-pharmacy-first-scotland-information-patients/ https://www.nhsinform.scot/care-support-and-rights/nhs-services/pharmacy/nhs-pharmacy-first-scotland https://link.springer.com/article/10.1007/s11096-011-9513-2 https://emahsn.org.uk/images/Digital_UTI_Pathway_Evaluation_-_Final_v270720.pdf (this tho is !!!) https://bmjopenquality.bmj.com/content/9/1/e000833 https://gov.wales/wider-range-services-be-provided-pharmacies-across-wales

Semaglutide at NICE and here in BNF Trial of weight regain after stopping STEP1 trial and STEP4 trial and STEP5 trial Novartis activity in run up Evusheld MHRA approval NICE appraisal Barclay letter RAPID c19 appraisal https://www.gov.uk/government/publications/rapid-c-19-oversight-group-report-to-chief-medical-officer-review-of-evusheld

…no. Law/guidance on food supplements here’s the paper

Links overviews , and here Sildenafil – current trials Uses of sildenafil in cardiovascular disease with pulmonary hypertension Thalidomide Good overview https://pubs.rsc.org/en/content/chapterhtml/2022/bk9781788019033-00001?isbn=978-1-78801-903-3&sercode=bk#cit7 and re myeloma leprosy mirena coil NHS policy and here overall drug development stats

Redirect study https://www.gla.ac.uk/researchinstitutes/healthwellbeing/news/headline_798822_en.html, https://redirectstudy.co.uk/ NIHR list here of trials  https://www.nihr.ac.uk/news/196-million-awarded-to-new-research-studies-to-help-diagnose-and-treat-long-covid/282

references: BJSM systematic review and meta analysis Definitions https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4269139/ International practice guidelines https://link.springer.com/content/pdf/10.1007/s12603-018-1139-9.pdf Screening – tests perform poorly BMJ analysis Arguments for it as a disease systematic review on resistance training for adults and for prevention/treatment and https://pubmed.ncbi.nlm.nih.gov/28549707/ and https://eurapa.biomedcentral.com/articles/10.1186/s11556-020-00243-9 and https://bjsm.bmj.com/content/54/15/885.abstract RCT on nutritional/exercise/cognitive intervention and another intervention trial Cochrane review on strength training […]

Had intended to be in London but lots of cancelled trains and I had to be back in Glasgow at the weekend. So attended remotely, it’s never quite the same. As ever I try never to repeat points someone else has made. It’s enough I think to say you agree and move on. Otherwise it […]

Links to things I’ve written before: Waterlogged? BMJ the mad colour chart (zillions of versions online, how much money have the NHS spent creating these? ffs) BMJ on this and some links to the primary science: First report I can find of using colour charts of some type to assess urine colour studies in 1990s […]

Lancet report https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02724-0/fulltext persistent urban myth that green sputum means you have a chest infection that needs antibiotics not the case. Special rules if you have serious lung condition eg cystic fibrosis or COPD, but for people who are otherwise well, green sputum does not = a need for antibiotics.  https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-021-01767-6 and https://erj.ersjournals.com/content/39/6/1354) the colour can’t distinguish between viral and bacterial […]