the key trials are these two COMPASS and US retrospective study  pharmaceutical journal report medication safety report  NICE guidance growth in DOAC use  other issues https://www.amjmed.com/article/S0002-9343(15)00926-2/fulltext risk of bleeding scores after blood clots https://www.thrombosisresearch.com/article/S0049-3848(17)30047-6/fulltext https://link.springer.com/article/10.1007/s10840-014-9930-y This systematic review focused the high bleeding-risk category of commonly used risk scores in AF. Our main findings were as follows: (1) Overall […]

the key trials are these two COMPASS and US retrospective study  pharmaceutical journal report medication safety report  NICE guidance growth in DOAC use  other issues https://www.amjmed.com/article/S0002-9343(15)00926-2/fulltext risk of bleeding scores after blood clots https://www.thrombosisresearch.com/article/S0049-3848(17)30047-6/fulltext https://link.springer.com/article/10.1007/s10840-014-9930-y This systematic review focused the high bleeding-risk category of commonly used risk scores in AF. Our main findings were as follows: […]

https://www.longtermplan.nhs.uk/online-version/ https://www.england.nhs.uk/2019/09/nhs-to-review-making-statins-available-direct-from-pharmacists-as-part-of-long-term-plan-to-cut-heart-disease/ https://www.nice.org.uk/guidance/cg181/chapter/1-Recommendations#identifying-and-assessing-cardiovascular-disease-cvd-risk-2

The UK is no longer classed as measles-free : The last few years have seen a decline in children having the MMR vaccination. https://www.bmj.com/content/362/bmj.k3967 In 2018 there were 991 confirmed cases of measles in England and Wales, compared with 284 cases in 2017.  This means that the UK has lost it’s measles free status,  which had […]

This is what I said, sorry if it’s disjointed, no point repeating what anyone else has said. So   Royal Patrons – if RCGP ever asked for, must ensure that process includes a commitment to evidence based healthcare 2) China process: concerns this is being seen as a commercial enterprise ; my belief is that […]

  overall advice updated advice here – http://www.bad.org.uk/for-the-public/skin-cancer/sunscreen-fact-sheet debate about UV light, melanoma, and sunscreen https://www.bmj.com/bmj/section-pdf/186530?path=/bmj/337/7663/Head_to_Head.full.pdf background https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041476/ case control study http://cebp.aacrjournals.org/content/early/2010/05/21/1055-9965.EPI-09-1249.abstract review article https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjd.16111 RCT follow up with subgroup analysis https://www.ncbi.nlm.nih.gov/pubmed/21135266 also some evidence re reducing risk of squamous cell carcinoma https://jamanetwork.com/journals/jamadermatology/fullarticle/479276 https://www.cochrane.org/CD011161/SKIN_sun-protection-including-sunscreens-prevent-basal-cell-carcinoma-and-cutaneous-squamous-cell early studies shown sunscreen increased melanoma use https://jamanetwork.com/journals/jamadermatology/article-abstract/478092 bias – in that […]

https://www.nhs.uk/using-the-nhs/help-with-health-costs/get-help-with-prescription-costs/ https://www.nhs.uk/using-the-nhs/help-with-health-costs/save-money-with-a-prescription-prepayment-certificate-ppc/ https://www.gov.uk/government/speeches/nhs-prescription-charges-from-april-2019

NSAIDs in pregnancy significant risk of miscarriage –  https://www.ncbi.nlm.nih.gov/pubmed/29890124 (small numbers but one series raised risk from 15% to 23% )  https://www.bmj.com/content/327/7411/368.long science of ovulation and NSAIDS https://link.springer.com/article/10.2165%2F00002018-200225080-00001 https://www.ncbi.nlm.nih.gov/pubmed/16493584 case series 2006 https://www.ncbi.nlm.nih.gov/pubmed/8646437 https://www.ncbi.nlm.nih.gov/pubmed/8624628 https://academic.oup.com/rheumatology/article/39/8/880/1784112 conference abstract, seems to have remained otherwise unpublished Salman S, Sherif B, Al-Zohyri A. Effects of some non steroidal anti-inflammatory […]

Mobile phones and sperm quality smoking *(where are all the other studies there should be on this?) animal research  Hazardous substances advisory committee and WHO  WHO reference ranges over time and overview  Endocrine Society report  and background http://ijomeh.eu/Environmental-exposure-to-non-persistent-endocrine-disrupting-chemicals-and-semen,76451,0,2.html tiny studies looking at dose related effects of  diethylhexyl phthalate (DEHP) and polychlorinated biphenyl 153 (PCB153) https://www.nature.com/articles/s41598-019-39913-9 -> poorer […]

for Inside Health 9/7/19 Previous column about similar CRUK campaign  Genetics and obesity  environment, genetics and obesity  CRUK own webpages on preventable risk factors – note alcohol + low fibre diet is a bigger risk factor than obesity…what about messages which are more realistically achieved? weight stigma and healthcare ironic effects of weight stigma perceived […]