Government press release https://www.gov.uk/government/news/worlds-first-coronavirus-human-challenge-study-receives-ethics-approval-in-the-uk Ethical issues https://www.thelancet.com/journals/laninf/article/PIIS1473-30992030438-2/fulltext Pfizer study – the numbers! https://www.nejm.org/doi/full/10.1056/NEJMoa2034577 Nuremberg trials and code https://www.nejm.org/doi/full/10.1056/nejm199711133372006 ethical frameworks https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926904/ https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30518-X/fulltext other types human challenge trials hookworm, – https://academic.oup.com/ofid/article/5/5/ofy083/4976553 malaria https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195259/ but also RSV – many trials of deliberately infecting humans https://clinicaltrials.gov/ct2/show/NCT02755948 Click to access 77021661.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904492/ Helicobacter story https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661189/ Click to access en_v31n3a02.pdf […]

Government consultation on ‘minipill’ – POP https://www.gov.uk/government/news/views-sought-on-making-the-oral-contraceptive-pill-desogestrel-available-from-pharmacies recommendations of extended use of implant and (some!) coils https://www.fsrh.org/documents/fsrh-ceu-recommendation-on-extended-use-of-the-etonogestrel/ service standards for family planning+sexual health during covid-19https://www.fsrh.org/documents/fsrh-guidance-essential-srh-services–third-covid-19-lockdown/ and https://www.fsrh.org/documents/fsrh-update-provision-of-contraception-during-covid19/

NICE /SIGN/RCGP guideline https://www.nice.org.uk/guidance/ng188/chapter/rationales#follow-up-and-monitoring-2 experience with recovery from other eg pneumonia t 50% of people who had pneumonia assessed as having ‘low severity ‘ of illness still experienced fatigue at 3m (mix of in and outpatients) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1497132/ Canadian study patients with pneumonia not admitted to hospital 2/3 better at day 14, half patients back at […]

CDC symptom checker : https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html (recommends a test if you have a sniffle) ONS Data – 27th Jan https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19infectionsinthecommunityinengland/characteristicsofpeopletestingpositiveforcovid19inengland27january2021 Biobank https://www.ukbiobank.ac.uk/media/x0nd5sul/ukb_serologystudy_report_revised_6months_jan21.pdf RCGP flu surveillance Covid 19 symptom survey https://b6bdcb03-332c-4ff9-8b9d-28f9c957493a.filesusr.com/ugd/3d9db5_bf013154aed5484b970c0cf84ff109e9.pdf

iodine based (povidone-iodine) British Dental Journal december worked quickly https://www.nature.com/articles/s41415-020-2402-0- lab based study JAMA https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2770785 lab based study upcoming 40 volunteers Stanford – iodine based nasal sprays in people with covid – measure amount of virus present in nasopharynx https://clinicaltrials.gov/ct2/show/NCT04347954?term=iodine+covid&draw=2&rank=13 theoretical framework https://journalotohns.biomedcentral.com/articles/10.1186/s40463-020-00474-x Nitric oxide releasing solutions – https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-004994-27/GB https://www.royalholloway.ac.uk/about-us/news/new-nasal-spray-proven-to-kill-999-of-the-coronavirus-that-causes-covid-19-is-being-trialled-in-the-uk/ salt water solution ELVIS covid […]

conclusion: this needs tested, may do more harm than good,  and cannot be assumed to ‘work’ Government announcement https://www.gov.uk/government/news/asymptomatic-testing-to-be-rolled-out-across-the-country-starting-this-week including “With the expansion of asymptomatic testing for those unable to work from home, added to our comprehensive COVID-Secure guidance, we can keep our economy on the move while giving individuals in key sectors complete confidence […]

initial publications https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgaa733/5934827 UK biobank Our findings do not support a potential link between vitamin D concentrations and risk of COVID-19 infection, nor that vitamin D concentration may explain ethnic differences in COVID-19 infection. https://pubmed.ncbi.nlm.nih.gov/32413819/ Lancet https://www.thelancet.com/journals/landia/article/PIIS2213-8587(20)30268-0/fulltext systematic review on vitamin D supplementation and preventing acute resp infections BMJ 2017 https://www.bmj.com/content/356/bmj.i6583 Meta-analysis of IPD from […]

https://www.cochrane.org/CD003048/INFECTN_do-probiotics-help-treat-acute-infectious-diarrhoea https://gutscharity.org.uk/advice-and-information/health-and-lifestyle/gut-microbiome-poo-testing/#section-5 https://www.bsg.org.uk/strategic-areas/research/gut-microbiota-for-health-expert-panel/ https://pubmed.ncbi.nlm.nih.gov/23439798/ https://www.nature.com/articles/s41591-020-0934-0 https://clevrblends.com/pages/faq https://academic.oup.com/cdn/article/4/Supplement_2/1547/5844467 https://academic.oup.com/cdn/article/4/Supplement_2/1518/5845874 https://www.cell.com/cell/fulltext/S0092-8674(15)01481-6#fig5 https://www.cell.com/cell/fulltext/S0092-8674(15)01481-6#secsectitle0035 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991026/

re compulsory vaccination -links here http://margaretmccartney.com/2019/09/24/compulsory-mmr-inside-health-24919/ Cochrane https://www.cochranelibrary.com/central/doi/10.1002/central/CN-01400885/full https://www.cochrane.org/CD010038/COMMUN_face-face-interventions-inform-or-educate-parents-about-early-childhood-vaccination Canada https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041657/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515949/ trust https://www.sciencedirect.com/science/article/pii/S0264410X1630977X rational questions https://www.bmj.com/content/371/bmj.m4058?ijkey=0e94d3615b1536944c62ffab1d3aa37b30140849&keytype2=tf_ipsecshan MMR and Wales https://www.bmj.com/content/346/bmj.f2598

Another council on zoom. It is bizarrely stressful/tiring. anyway Very very pleased to have presented motion to council on appraisal. This was very kindly seconded by Dr Carter Singh who has also been raising concerns for some time. This motion had been several months in the organising and had originated with Carter and myself. A […]