Quarantine – historical https://journals.sagepub.com/doi/pdf/10.1177/003591574503800701 WHO and international vaccine certification https://link.springer.com/chapter/10.1007/978-3-642-73772-5_120 https://journals.sagepub.com/doi/pdf/10.1177/003591574503800701 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7454779/ Click to access Green-Book-Chapter-14v2_0.pdf WHO and current guidance https://www.who.int/news-room/articles-detail/interim-position-paper-considerations-regarding-proof-of-covid-19-vaccination-for-international-travellers UK currently reviewing ‘complex issues’ https://www.bbc.co.uk/news/55970801 previous problems with IHR https://journals.sagepub.com/doi/full/10.1177/0098858816658273 loopholes with yellow fever vaccination https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31670-8/fulltext issues with apps and data security https://www.qmul.ac.uk/media/news/2021/se/new-tool-reveals-security-and-privacy-issues-with-contact-tracing-apps.html fantastic tracker from Ada Lovelace Institute https://www.adalovelaceinstitute.org/project/international-monitor-vaccine-passports-covid-status-apps/ Rabies vaccination and […]

Government press release https://www.gov.uk/government/news/worlds-first-coronavirus-human-challenge-study-receives-ethics-approval-in-the-uk Ethical issues https://www.thelancet.com/journals/laninf/article/PIIS1473-30992030438-2/fulltext Pfizer study – the numbers! https://www.nejm.org/doi/full/10.1056/NEJMoa2034577 Nuremberg trials and code https://www.nejm.org/doi/full/10.1056/nejm199711133372006 ethical frameworks https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926904/ https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30518-X/fulltext other types human challenge trials hookworm, – https://academic.oup.com/ofid/article/5/5/ofy083/4976553 malaria https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195259/ but also RSV – many trials of deliberately infecting humans https://clinicaltrials.gov/ct2/show/NCT02755948 Click to access 77021661.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904492/ Helicobacter story https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661189/ Click to access en_v31n3a02.pdf […]

Government consultation on ‘minipill’ – POP https://www.gov.uk/government/news/views-sought-on-making-the-oral-contraceptive-pill-desogestrel-available-from-pharmacies recommendations of extended use of implant and (some!) coils https://www.fsrh.org/documents/fsrh-ceu-recommendation-on-extended-use-of-the-etonogestrel/ service standards for family planning+sexual health during covid-19https://www.fsrh.org/documents/fsrh-guidance-essential-srh-services–third-covid-19-lockdown/ and https://www.fsrh.org/documents/fsrh-update-provision-of-contraception-during-covid19/

NICE /SIGN/RCGP guideline https://www.nice.org.uk/guidance/ng188/chapter/rationales#follow-up-and-monitoring-2 experience with recovery from other eg pneumonia t 50% of people who had pneumonia assessed as having ‘low severity ‘ of illness still experienced fatigue at 3m (mix of in and outpatients) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1497132/ Canadian study patients with pneumonia not admitted to hospital 2/3 better at day 14, half patients back at […]

CDC symptom checker : https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html (recommends a test if you have a sniffle) ONS Data – 27th Jan https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19infectionsinthecommunityinengland/characteristicsofpeopletestingpositiveforcovid19inengland27january2021 Biobank https://www.ukbiobank.ac.uk/media/x0nd5sul/ukb_serologystudy_report_revised_6months_jan21.pdf RCGP flu surveillance Covid 19 symptom survey https://b6bdcb03-332c-4ff9-8b9d-28f9c957493a.filesusr.com/ugd/3d9db5_bf013154aed5484b970c0cf84ff109e9.pdf

iodine based (povidone-iodine) British Dental Journal december worked quickly https://www.nature.com/articles/s41415-020-2402-0- lab based study JAMA https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2770785 lab based study upcoming 40 volunteers Stanford – iodine based nasal sprays in people with covid – measure amount of virus present in nasopharynx https://clinicaltrials.gov/ct2/show/NCT04347954?term=iodine+covid&draw=2&rank=13 theoretical framework https://journalotohns.biomedcentral.com/articles/10.1186/s40463-020-00474-x Nitric oxide releasing solutions – https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-004994-27/GB https://www.royalholloway.ac.uk/about-us/news/new-nasal-spray-proven-to-kill-999-of-the-coronavirus-that-causes-covid-19-is-being-trialled-in-the-uk/ salt water solution ELVIS covid […]

conclusion: this needs tested, may do more harm than good,  and cannot be assumed to ‘work’ Government announcement https://www.gov.uk/government/news/asymptomatic-testing-to-be-rolled-out-across-the-country-starting-this-week including “With the expansion of asymptomatic testing for those unable to work from home, added to our comprehensive COVID-Secure guidance, we can keep our economy on the move while giving individuals in key sectors complete confidence […]

initial publications https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgaa733/5934827 UK biobank Our findings do not support a potential link between vitamin D concentrations and risk of COVID-19 infection, nor that vitamin D concentration may explain ethnic differences in COVID-19 infection. https://pubmed.ncbi.nlm.nih.gov/32413819/ Lancet https://www.thelancet.com/journals/landia/article/PIIS2213-8587(20)30268-0/fulltext systematic review on vitamin D supplementation and preventing acute resp infections BMJ 2017 https://www.bmj.com/content/356/bmj.i6583 Meta-analysis of IPD from […]

https://www.cochrane.org/CD003048/INFECTN_do-probiotics-help-treat-acute-infectious-diarrhoea https://gutscharity.org.uk/advice-and-information/health-and-lifestyle/gut-microbiome-poo-testing/#section-5 https://www.bsg.org.uk/strategic-areas/research/gut-microbiota-for-health-expert-panel/ https://pubmed.ncbi.nlm.nih.gov/23439798/ https://www.nature.com/articles/s41591-020-0934-0 https://clevrblends.com/pages/faq https://academic.oup.com/cdn/article/4/Supplement_2/1547/5844467 https://academic.oup.com/cdn/article/4/Supplement_2/1518/5845874 https://www.cell.com/cell/fulltext/S0092-8674(15)01481-6#fig5 https://www.cell.com/cell/fulltext/S0092-8674(15)01481-6#secsectitle0035 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991026/

re compulsory vaccination -links here http://margaretmccartney.com/2019/09/24/compulsory-mmr-inside-health-24919/ Cochrane https://www.cochranelibrary.com/central/doi/10.1002/central/CN-01400885/full https://www.cochrane.org/CD010038/COMMUN_face-face-interventions-inform-or-educate-parents-about-early-childhood-vaccination Canada https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041657/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515949/ trust https://www.sciencedirect.com/science/article/pii/S0264410X1630977X rational questions https://www.bmj.com/content/371/bmj.m4058?ijkey=0e94d3615b1536944c62ffab1d3aa37b30140849&keytype2=tf_ipsecshan MMR and Wales https://www.bmj.com/content/346/bmj.f2598