iodine based (povidone-iodine)

British Dental Journal december
worked quickly
https://www.nature.com/articles/s41415-020-2402-0- lab based study
JAMA
https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2770785
lab based study

upcoming
40 volunteers Stanford – iodine based nasal sprays in people with covid – measure amount of virus present in nasopharynx

https://clinicaltrials.gov/ct2/show/NCT04347954?term=iodine+covid&draw=2&rank=13

theoretical framework
https://journalotohns.biomedcentral.com/articles/10.1186/s40463-020-00474-x

Nitric oxide releasing solutions –
https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-004994-27/GB

https://www.royalholloway.ac.uk/about-us/news/new-nasal-spray-proven-to-kill-999-of-the-coronavirus-that-causes-covid-19-is-being-trialled-in-the-uk/

salt water solution
ELVIS covid 2 study in ediburgh
looking for adults self isolating due to early covid symptoms (last 2 days)
https://www.ed.ac.uk/usher/elvis-covid-19

previous study with gargling for cold – small, pilot but did reduce time of sx
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355924/

https://www.nature.com/articles/s41598-018-37703-3

0.07% cetypyridinium chloride
dental mouthwash – in vitro
https://www.biorxiv.org/content/10.1101/2020.11.13.381079v1

German study – best listerine (alcohol and essential oils, dequonal – benzalkonium chloride
isobetadine mouth wash (iodine based)

https://academic.oup.com/jid/article/222/8/1289/5878067

hydrogen peroxide

Germany tiny study didn’t work
https://pubmed.ncbi.nlm.nih.gov/32876748/
systematic rv in Dec 2020 – no evidence found that could work against covid
https://pubmed.ncbi.nlm.nih.gov/33058941/

birmingham group – polymer

Click to access 2020.11.18.388645v1.full.pdf

mucoadhesive chemicals , viscous polymers

carrageenan
Swansea university – really interesting as RCT propylaxis in 480 healthcare workers due to complete in November
not yet recruiting
https://clinicaltrials.gov/ct2/show/NCT04590365

BUT 2015 – told by ASA not to say that it can not say
clinically proven to defend against cold and flu
not robust enough evidence
https://www.asa.org.uk/rulings/boots-uk-ltd-a14-289827.html

Gonnohoea – bacteria

https://pubmed.ncbi.nlm.nih.gov/28245320/

saline douches – nasal irrigation for nasal allergies
https://www.nds.ox.ac.uk/news/cochrane-review-shows-the-benefits-of-nasal-saline-in-allergic-rhinitis/search?tab=blogpost&category=research&categories=research

Japan h1n1 2009 – recommended gargling with antimicrobial agents
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750655/

provide as good was water gargling tds throughout winter in japan
https://pubmed.ncbi.nlm.nih.gov/16242593/

studies underway

using different antiseptic mouthwashes against covid

https://clinicaltrials.ucsf.edu/trial/NCT04409873

Overview
https://academic.oup.com/function/article/1/1/zqaa002/5836301

Augustus university
https://clinicaltrials.gov/ct2/show/NCT04559035?term=iodine+covid&draw=2&rank=22

salt water trial in humans – ongoing – Betadine / salt water – for people testing positive for covid 19
https://clinicaltrials.gov/ct2/show/NCT04559035?term=iodine+covid&draw=2&rank=22

iodine trial in 24 covid positive humans – using mouthwash / gangle / spray

https://clinicaltrials.gov/ct2/show/NCT04371965?term=iodine+covid&draw=2&rank=5

GARGLES study Pakistan
https://clinicaltrials.gov/ct2/show/NCT04341688

gargles study Malaysia 20 positive patients
essential oil , vs tap water, vs iodine
https://clinicaltrials.gov/ct2/show/NCT04410159?term=iodine+covid&draw=2&rank=7

COCHRANE

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013626.pub2/full
NOTE – only one of the ongoing studies specifically states that it will evaluate adverse events