for inside health 30th Jan 24 NICE guidance https://cks.nice.org.uk/topics/menopause/prescribing-information/hormone-replacement-therapy-hrt/ https://cks.nice.org.uk/topics/menopause/ “Prescribing the lowest dose for the shortest possible duration.” Noted this survey being quoted a lot in the papers I was reading – important to note Covid vaccination and menstrual changes https://bmjmedicine.bmj.com/content/1/1/e000297 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294036/#bb0075 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8936155/ https://www.frontiersin.org/articles/10.3389/fmed.2022.1065421/full https://www.elsevier.es/en-revista-vacunas-english-edition–259-articulo-menstrual-abnormalities-after-covid-19-vaccines-S2445146022000887?covid=Dr56DrLjUdaMjzAgze452SzSInMN&rfr=truhgiz&y=kEzTXsahn8atJufRpNPuIGh67s1
Continue Reading →Response to government consultation on DOIs
closes on https://www.gov.uk/government/consultations/the-disclosure-of-industry-payments-to-the-healthcare-sector/disclosure-of-industry-payments-to-the-healthcare-sector#how-to-respond – CLOSES 16th OCT 23 -We agree that information about payments and benefits from “healthcare provider organisations and organisations connected to the provision of healthcare” should be publicly available. -However the document concentrates on pharmaceutical companies. It is important to consider the potential for conflicts to arise in numerous other domains. For […]
Continue Reading →JRSM
Healthcare and feminism Margaret McCartney Volume 116, Issue 7 In the last decade, it has become common for politicians to don t-shirts claiming that they are what feminists look like. The bra-burning of the 1960s had faded into a fashion statement, but what about the politics of it? I remember being introduced to feminism by my mother, who told […]
Continue Reading →Semaglutide – Inside Health 7/3/23
NICE https://www.nice.org.uk/guidance/indevelopment/gid-ta10765 NEJM Step1 https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 Step 1 extension https://pubmed.ncbi.nlm.nih.gov/35441470/ Step 5 trial (2 years) https://www.nature.com/articles/s41591-022-02026-4#:~:text=Safety%20and%20tolerability,placebo%20group%20(Table%203). Weight loss outcomes Real world outcomes in type 2 diabetes https://drc.bmj.com/content/10/1/e002517 on side effects
Continue Reading →Inside Health 18/10/22
https://www.sehd.scot.nhs.uk/publications/NHS_Pharmacy_First_Scotland_Approved_List_of_Products_v13_(1_Dec_2021).pdf https://www.nhsinform.scot/care-support-and-rights/nhs-services/pharmacy/nhs-pharmacy-first-scotland https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692826/ https://pubmed.ncbi.nlm.nih.gov/29362007/ https://bmjopenquality.bmj.com/content/9/1/e000833 https://www.communitypharmacy.scot.nhs.uk/media/1104/pharmacy-first-guidance-document-lk-v3comments-1.pdf https://www.gov.scot/publications/nhs-pharmacy-first-scotland-information-patients/ https://www.nhsinform.scot/care-support-and-rights/nhs-services/pharmacy/nhs-pharmacy-first-scotland https://link.springer.com/article/10.1007/s11096-011-9513-2 https://emahsn.org.uk/images/Digital_UTI_Pathway_Evaluation_-_Final_v270720.pdf (this tho is !!!) https://bmjopenquality.bmj.com/content/9/1/e000833 https://gov.wales/wider-range-services-be-provided-pharmacies-across-wales
Continue Reading →Inside Health 13/10/22
Semaglutide at NICE and here in BNF Trial of weight regain after stopping STEP1 trial and STEP4 trial and STEP5 trial Novartis activity in run up Evusheld MHRA approval NICE appraisal Barclay letter RAPID c19 appraisal https://www.gov.uk/government/publications/rapid-c-19-oversight-group-report-to-chief-medical-officer-review-of-evusheld
Continue Reading →‘hangover cure’
…no. Law/guidance on food supplements here’s the paper
Continue Reading →Drug repurposing Inside Health 4/8/22
Links overviews , and here Sildenafil – current trials Uses of sildenafil in cardiovascular disease with pulmonary hypertension Thalidomide Good overview https://pubs.rsc.org/en/content/chapterhtml/2022/bk9781788019033-00001?isbn=978-1-78801-903-3&sercode=bk#cit7 and re myeloma leprosy mirena coil NHS policy and here overall drug development stats
Continue Reading →Inside Health 26/7/22
Redirect study https://www.gla.ac.uk/researchinstitutes/healthwellbeing/news/headline_798822_en.html, https://redirectstudy.co.uk/ NIHR list here of trials https://www.nihr.ac.uk/news/196-million-awarded-to-new-research-studies-to-help-diagnose-and-treat-long-covid/282
Continue Reading →Sarcopenia / strength training
references: BJSM systematic review and meta analysis Definitions https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4269139/ International practice guidelines https://link.springer.com/content/pdf/10.1007/s12603-018-1139-9.pdf Screening – tests perform poorly BMJ analysis Arguments for it as a disease systematic review on resistance training for adults and for prevention/treatment and https://pubmed.ncbi.nlm.nih.gov/28549707/ and https://eurapa.biomedcentral.com/articles/10.1186/s11556-020-00243-9 and https://bjsm.bmj.com/content/54/15/885.abstract RCT on nutritional/exercise/cognitive intervention and another intervention trial Cochrane review on strength training […]
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