Australian frailty intervention trial

http://www.biomedcentral.com/1741-7015/11/65

other intervention trials for frailty of note

http://www.nejm.org/doi/full/10.1056/NEJMoa020423#t=articleMethods

http://www.sciencedirect.com/science/article/pii/S0003999306003510

http://www.nejm.org/doi/pdf/10.1056/NEJM199406233302501

systematic review from 2008

http://www.biomedcentral.com/1472-6963/8/278

and 2012

http://www.sciencedirect.com/science/article/pii/S2210833512000238

“Slow walking speed (less than 0.8m/s or taking more than 5 secs to walk 4m); the PRISMA 7 questionnaire and the timed-up-and-go test (with a cut off score of 10 secs) had very good sensitivity but only moderate specificity for identifying frailty. This means that there are many fitter older people who will have a positive test result (false positives). For example, only one in 3 older people (over 75 years) with slow walking speed has frailty”

Click to access fff_full.pdf

END OF LIFE COSTS

lots of hypotheticals

http://www.nuffieldtrust.org.uk/publications/exploring-cost-care-end-life

Click to access 07081043_potentialsavings.pdf

Social care Institute of Excellence

http://www.scie.org.uk/publications/guides/guide48/costsofdyingathome.asp

USA situation

http://jop.ascopubs.org/content/4/3/153.full

http://jama.jamanetwork.com/article.aspx?articleid=1930818

OFF LABEL DRUG USE
https://www.gov.uk/drug-safety-update/off-label-or-unlicensed-use-of-medicines-prescribers-responsibilities

GMC guidance

http://www.gmc-uk.org/guidance/ethical_guidance/14327.asp