Important paper in JAMA: ovarian cancer screening using transvaginal ultrasound and serum Ca-125 testing does not reduce mortality from ovarian cancer.
Worse, there “Diagnostic evaluation following a false-positive screening test result was associated with complications”. The harms of this ineffective intervention:
“Of 3285 women with false-positive results, 1080 underwent surgery (32.9% for oophorectomy) as part of the diagnostic workup. Of these 1080 women, 163 (15%) experienced a total of 222 distinct major complications, which yielded a rate of 20.6 complications per 100 surgical procedures”.
That’s a lot of operations and a relatively high risk of complications.
I wonder when we will realise that most screening is overhyped, overvalued, and not very useful.